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Synthesis and characterization of new methotrexate derivatives containing divalent cations and their evaluation as bioactive compounds for musculoskeletal regeneration.
|Authors:||Fernández-Villa, Daniel; Ramírez Jiménez, Rosa Ana; Aranaz Corral, Inmaculada; Acosta Contreras, Florentina Niuris; Vázquez Lasa, Blanca; Rojo del Olmo, Luis|
|Citation:||13th International Symposium on Frontiers in Biomedical Polymers, Puerto de la Cruz, Canary Islands (SPAIN) 18-23 may, 2019|
|Abstract:||In the present work, methotrexate derivatives containing divalent cations (strontium, zinc and magnesium) were synthesized and characterized by different physicochemical techniques. In addition, strontium and zinc-derivatives biological activities were tested in vitro and encapsulated into chitosan microparticles as a both biocompatible and biodegradable system for their ulterior sustained release.|
|Appears in Collections:||(ICTP) Comunicaciones congresos|