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Novel solid forms of an antiretroviral drug: solvates, cocrystals and eutectic systems

AuthorsCosta, R. N.; Choquesillo-Lazarte, Duane ; Infantes, L. ; Cuffini, S.L.
Eutectic systems
Issue Date8-Oct-2019
CitationIV Meeting of the Latin American Crystallographic Association (2019)
AbstractNevirapine (11-Cyclopropyl-4-methyl-5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one) (NVP) is an antiretroviral used to treat HIV-1 infection [1]. According to the Biopharmaceutical Classification System (BCS) [2], NVP is classified as a class II drug [3], which means it presents low solubility and high permeability. The low solubility implies in problems during formulation and resulting in a decreasing in the bioavailability. Solid-state modifications have been used in pharmaceutical area as a strategy to improve drug properties. Among the possible modifications there is the formation of multicomponent forms, including cocrystals, solvates and eutectic systems (figure 1). Several multicomponent structures containing the NVP have been described in literature. In a screening of new multicomponent forms of NVP, four co-crystals, five solvates and two eutectic systems have been found. Characterization of materials were performed using optical microscopy, powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC) and Raman spectroscopy. Crystalline structures were determined single X-ray diffraction (SXRD) data.
DescriptionLACA 2019, Bucaramanga, Colombia, October 7th-10th, 2019. -- https://ivlaca2019.co/
Appears in Collections:(IQFR) Comunicaciones congresos
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