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Title: | A Lupine (Lupinus angustifolius L.) peptide prevents non-alcoholic fatty liver disease in high-fat diet-induced obese mice |
Authors: | Lemus-Conejo, Ana; Grao‐Cruces, Elena; Toscano, Rocío; Varela, Lourdes; Claro, Carmen; Pedroche, Justo ![]() ![]() ![]() ![]() |
Issue Date: | 2020 |
Publisher: | Royal Society of Chemistry (UK) |
Citation: | Food and Function 11 (4): 2943-2952 (2020) |
Abstract: | Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg−1 day−1 or 1 mg kg−1 day−1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways. |
Description: | 10 Páginas.-- 7 Figuras.-- 1 Tabla |
Publisher version (URL): | http://dx.doi.org/10.1039/D0FO00206B |
URI: | http://hdl.handle.net/10261/210456 |
DOI: | http://dx.doi.org/10.1039/D0FO00206B |
Identifiers: | doi: 10.1039/D0FO00206B issn: 2042-650X |
Appears in Collections: | (IBIS) Artículos (IG) Artículos |
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File | Description | Size | Format | |
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FF_2020_V11_2943.pdf | 3,52 MB | Adobe PDF | ![]() View/Open | |
FF_2020_V11_2943_Suppl.pdf | 112,33 kB | Adobe PDF | ![]() View/Open |
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