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A Lupine (Lupinus angustifolius L.) peptide prevents non-alcoholic fatty liver disease in high-fat diet-induced obese mice

AuthorsLemus-Conejo, Ana; Grao‐Cruces, Elena; Toscano, Rocío; Varela, Lourdes; Claro, Carmen; Pedroche, Justo ; Millán, Francisco ; Millán-Linares, María del Carmen ; Montserrat-de la Paz, Sergio
Issue Date2020
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function 11 (4): 2943-2952 (2020)
AbstractBioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg−1 day−1 or 1 mg kg−1 day−1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways.
Description10 Páginas.-- 7 Figuras.-- 1 Tabla
Publisher version (URL)http://dx.doi.org/10.1039/D0FO00206B
Identifiersdoi: 10.1039/D0FO00206B
issn: 2042-650X
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