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Computational analysis of sumoylation in protein kinases: a biomedical perspective

AuthorsMedina, Patricia; Barrios Núñez, Israel; Rojas, A. M.
Issue Date17-Oct-2019
CitationVII Bioinformatics Students Sympossium (2019)
AbstractSumoylation is a general post-translational modification that regulates many biological processes, by blocking interaction sites, creating novel interaction events, or inducing conformational changes [3]. Kinases are pivotal in signalling and development. For instance, Aurora-B kinase, MEK, FAK areimportant and known to be sumoylated [2]. Here we address an interactive web graphical user interface 1) identified potential sumoylation sites, 2) their associated 3D structural properties, 3) their distribution in cancer samples, and 4) their distributions along the different subfamilies. We have observed a differential regulation within the kinases’ subfamilies, with a preferentiallocalization around the active site. Interestingly sumoylated sites are buried within the protein, regardless of their localization (except CAMK subfamily), suggesting the possibility of allosteric events for sumoylation to occur. Mutation rate in potential sumoylation sites in cancer is not significant
DescriptionResumen del trabajo presentado en el VII Bioinformatics Students Sympossium, celebrado en Madrid (España), el 17 de octubre de 2019
Appears in Collections:(CABD) Comunicaciones congresos
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