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Title

Immunochemical diagnostic and therapy strategies based on Quorum Sensing

AuthorsRodriguez, Bárbara; Montagut, Enric; Berardi, Ginevra; Royo, Miriam ; Vilaplana, Lluïsa; Marco, María Pilar
Issue Date21-Oct-2019
AbstractWorldwide infectious diseases are one of the major concerns entailing a dramatic impact on society. Particularly, respiratory infections, caused by the pathogenic bacteria Pseudomonas aeruginosa and Staphylococcus aureus, are responsible of more than 3 millions deaths per year1. In order to better monitor and manage these diseases, there is still the need of reliable diagnostic tools able to early detect the presence of these bacteria in biological samples and innovative therapeutic strategies to avoid the development of bacterial resistance processes. A promising approach consists on interrupting or attenuating bacterial virulence pathways (antivirulence therapies). This can be achieved by affecting the bacterial communication system Quorum Sensing (QS), a regulation mechanism that coordinates the expression of a myriad of genes in response to the presence of small signal molecules known as autoinducers2. Moreover, the detection and quantification of these molecules can provide valuable information on disease state and the subsequent treatment. Currently, immunochemical tools targeting different QS components for both diagnostic and therapeutic purposes are being developed, exploiting the high binding affinity of an antibody towards its hapten.
URIhttp://hdl.handle.net/10261/210161
Appears in Collections:(IQAC) Comunicaciones congresos
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