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Synthetic hybrids of six yeast species

AuthorsPeris, David; Alexander, William G.; Fisher, Kaitlin J.; Moriarty, Ryan V.; Basuino, Mira G.; Ubbelohde, Emily J.; Wrobel, Russell L.; Hittinger, Chris Todd
KeywordsExperimental evolution
Genetic hybridization
Genomic instability
Synthetic biology
Issue Date29-Apr-2020
PublisherSpringer Nature
CitationNature Communications 11: 2085 (2020)
AbstractAllopolyploidy generates diversity by increasing the number of copies and sources of chromosomes. Many of the best-known evolutionary radiations, crops, and industrial organisms are ancient or recent allopolyploids. Allopolyploidy promotes differentiation and facilitates adaptation to new environments, but the tools to test its limits are lacking. Here we develop an iterative method of Hybrid Production (iHyPr) to combine the genomes of multiple budding yeast species, generating Saccharomyces allopolyploids of at least six species. When making synthetic hybrids, chromosomal instability and cell size increase dramatically as additional copies of the genome are added. The six-species hybrids initially grow slowly, but they rapidly regain fitness and adapt, even as they retain traits from multiple species. These new synthetic yeast hybrids and the iHyPr method have potential applications for the study of polyploidy, genome stability, chromosome segregation, and bioenergy.
DescriptionEste registro contiene el PDF editorial, el manuscrito aceptado y la información suplementaria (Supplementary text: 2 notas; Suplementary figures: 9 figuras; Referencias bibliográficas.)
Publisher version (URL)https://doi.org/10.1038/s41467-020-15559-4
Appears in Collections:(IATA) Artículos
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NatureComm2020-Peris.pdfArtículo principal - published PDF1,93 MBAdobe PDFThumbnail
Peris-Nature_manuscript.pdfArtículo principal-accepted manuscript2,28 MBAdobe PDFThumbnail
Peris_Nature-Suppl.pdfSupplementary information8,78 MBAdobe PDFThumbnail
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