English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/210047
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies

AuthorsCubillos-Zapata, Carolina; Angulo, Iván ; Almanza, Horacio; Borrego, Belén ; Zamora-Ceballos, María; Castón, José R.; Mena, Ignacio; Blanco, Esther; Bárcena, Juan
Issue Date2020
PublisherBioMed Central
CitationVeterinary Research 51(1): 59 (2020)
AbstractAbstract We report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5′HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recognized by non-neutralizing MAbs; and a second epitope spanning amino acids 445-451 (ITTANQY), highly variable and recognized by neutralizing MAbs. These antibodies might be valuable for diagnostic applications, as well as for further research in different aspects of the biology of FCV.
Publisher version (URL)https://doi.org/10.1186/s13567-020-00785-x
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
Precise_Cubillos_Art2020.pdf2,63 MBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.