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Title

Precise location of linear epitopes on the capsid surface of feline calicivirus recognized by neutralizing and non-neutralizing monoclonal antibodies

AuthorsCubillos-Zapata, Carolina; Angulo, Iván ; Almanza, Horacio; Borrego, Belén ; Zamora-Ceballos, María; Castón, José R; Mena, Ignacio; Blanco, Esther; Bárcena, Juan
Issue Date1-May-2020
PublisherBioMed Central
CitationVeterinary Research. 2020 May 01;51(1):59
AbstractAbstract We report the generation, characterization and epitope mapping of a panel of 26 monoclonal antibodies (MAbs) against the VP1 capsid protein of feline calicivirus (FCV). Two close but distinct linear epitopes were identified at the capsid outermost surface (P2 subdomain) of VP1, within the E5′HVR antigenic hypervariable region: one spanning amino acids 431-435 (PAGDY), highly conserved and recognized by non-neutralizing MAbs; and a second epitope spanning amino acids 445-451 (ITTANQY), highly variable and recognized by neutralizing MAbs. These antibodies might be valuable for diagnostic applications, as well as for further research in different aspects of the biology of FCV.
URIhttps://doi.org/10.1186/s13567-020-00785-x
http://hdl.handle.net/10261/210047
Appears in Collections:Colección Biomed Central-Chemistry Central-Springer Open
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