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Selection pressure in wild and domestic pigs

AuthorsLeno-Colorado, J.; Guirao-Rico, S.; Rodríguez, M. Carmen; Silió, Luis; Pérez-Enciso, Miguel ; Ramos-Onsins, Sebastian E.
Issue Date2019
CitationSMBE satellite meeting (2019)
AbstractDomestic animal histories are evolutionary experiments that have often lasted for millennia with the result of dramatic phenotypic changes to suit human needs. This history can be quite complex; many events remain unknown or poorly documented. They, therefore, offer a material of utmost interest to study the interplay of demography and accelerated adaptation. The pig (Sus scrofa) is a particularly interesting species and one in which there is abundant genetic tools and sequence data available. It originated in the Southeast Asian region ca. 4 MYA and migrated towards the west, colonizing all climates in Eurasia except the driest. Subsequently, the pig was domesticated out of local wild boars independently in both Asia and Europe ~9,000 years ago. The main purpose of this work is to detect the selective effect of the domestication. Domestication is an intense selection process that occurred in a short evolutive time and, as a result, it is expected that new mutations have been accumulated in a small proportion in relation to the mutations segregating at the whole genome. In all, a genome-wide appraisal of the relevance of protein coding changes associated with domestication is largely incomplete in animal species. To fill this gap, here we have investigated the patterns of selection genome-wide in domestic and wild pigs via the McDonald-Kreitman test (MKT), which exploits the fact that the ratio between non-synonymous and synonymous/silent mutations within a population is distorted under selection when compared to the same ratio in terms of divergence. Thus, we have analyzed the differential ratio of polymorphism-divergence of wild and domestic pigs at genomic, metabolic pathway and gene scale, in order to evaluate the effect of selection and of demographic patterns during the domestication process.
DescriptionResumen del póster presentado al SMBE satellite meeting ‘Towards an integrated concept of adaptation: uniting molecular population genetics and quantitative genetics’, celebrado en Viena (Austria) del 11 al 14 de febrero de 2019.
Appears in Collections:(CRAG) Comunicaciones congresos
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