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dc.contributor.author | Fragogeorgi, Eirini A. | - |
dc.contributor.author | Rouchota, Maritina | - |
dc.contributor.author | Georgiou, Maria | - |
dc.contributor.author | Vélez, Marisela | - |
dc.contributor.author | Bouziotis, Penelope | - |
dc.contributor.author | Loudos, George | - |
dc.date.accessioned | 2020-04-30T15:44:37Z | - |
dc.date.available | 2020-04-30T15:44:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier | doi: 10.1177/2041731419854586 | - |
dc.identifier | e-issn: 2041-7314 | - |
dc.identifier.citation | Journal of Tissue Engineering 10 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/209878 | - |
dc.description.abstract | [EN] Bone is a dynamic tissue that constantly undergoes modeling and remodeling. Bone tissue engineering relying on the development of novel implant scaffolds for the treatment of pre-clinical bone defects has been extensively evaluated by histological techniques. The study of bone remodeling, that takes place over several weeks, is limited by the requirement of a large number of animals and time-consuming and labor-intensive procedures. X-ray-based imaging methods that can non-invasively detect the newly formed bone tissue have therefore been extensively applied in pre-clinical research and in clinical practice. The use of other imaging techniques at a pre-clinical level that act as supportive tools is convenient. This review mainly focuses on nuclear imaging methods (single photon emission computed tomography and positron emission tomography), either alone or used in combination with computed tomography. It addresses their application to small animal models with bone defects, both untreated and filled with substitute materials, to boost the knowledge on bone regenerative processes. | - |
dc.description.sponsorship | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is part of a project that has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 645757. This study was co-supported through the Program of Industrial Scholarships of Stavros Niarchos Foundation and through IKY scholarships and co-financed by the European Union (European Social Fund ESF) and Greek national funds through the action entitled Reinforcement of Postdoctoral Researchers, in the framework of the Operational Program Human Resources Development Program, Education and Lifelong Learning of the National Strategic Reference Framework (NSRF) 2014-2020. | - |
dc.language | eng | - |
dc.publisher | Sage Publications | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/645757 | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Bone defects | - |
dc.subject | Single photon emission computed tomography/positron emission tomography | - |
dc.subject | Computed tomography imaging | - |
dc.subject | Healing | - |
dc.subject | Substitute materials | - |
dc.title | In vivo imaging techniques for bone tissue engineering | - |
dc.type | artículo de revisión | - |
dc.identifier.doi | 10.1177/2041731419854586 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1177/2041731419854586 | - |
dc.date.updated | 2020-04-30T15:44:37Z | - |
dc.rights.license | Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License http://www.creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.contributor.orcid | Fragogeorgi, Eirini A.[0000-0002-8272-746X] | - |
dc.identifier.pmid | 31258885 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_dcae04bc | es_ES |
item.openairetype | artículo de revisión | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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