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Title

Potential factors influencing replay across CA1 layers

AuthorsMenéndez de la Prida, Liset
Keywordsripples
replay
preplay
deep–superficial
Issue Date20-May-2019
PublisherRoyal Society (Great Britain)
CitationThis article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’. 20-21 de mayo de 2019. Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell, Buckinghamshire, MK16 9JJ
AbstractSharp-wave ripples are complex neurophysiological events recorded along the trisynaptic hippocampal circuit (i.e. from CA3 to CA1 and the subiculum) during slow-wave sleep and awake states. They arise locally but scale brain-wide to the hippocampal target regions at cortical and subcortical structures. During these events, neuronal firing sequences are replayed retrospectively or prospectively and in the forward or reverse order as defined by experience. They could reflect either pre-configured firing sequences, learned sequences or an option space to inform subsequent decisions. How can different sequences arise during sharp-wave ripples? Emerging data suggest the hippocampal circuit is organized in different loops across the proximal (close to dentate gyrus) and distal (close to entorhinal cortex) axis. These data also disclose a so-far neglected laminar organization of the hippocampal output during sharp-wave events. Here, I discuss whether by incorporating cell-type-specific mechanisms converging on deep and superficial CA1 sublayers along the proximodistal axis, some novel factors influencing the organization of hippocampal sequences could be unveiled.
DescriptionThis article is part of the Theo Murphy meeting issue ‘Memory reactivation: replaying events past, present and future’. 20-21 de mayo de 2019. Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell, Buckinghamshire, MK16 9JJ
URIhttp://hdl.handle.net/10261/209794
Appears in Collections:(IC) Comunicaciones congresos
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