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Title

2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents

AuthorsMthembu, Sinenhlanhla N.; Sharma, Anamika; Albericio, Fernando; de la Torre, Beatriz G.
KeywordsDABDT
Bioconjugate chemistry
Issue DateNov-2019
PublisherAmerican Chemical Society
CitationOrganic Letters 21 (24): 10111-10114 (2019)
AbstractDisulfide-reducing agents play a crucial role in bioconjugate chemistry. Herein, we describe the synthesis of a new disulfide-reducing agent [2-(dibenzylamino)butane-1,4-dithiol (DABDT)] that is conveniently prepared from inexpensive aspartic acid. Being nonmalodorous and highly soluble in a broad range of solvents, DABDT is user-friendly. We have demonstrated its performance both in solution and in the solid phase.
Publisher version (URL)10.1021/acs.orglett.9b04106
URIhttp://hdl.handle.net/10261/209785
DOI10.1021/acs.orglett.9b04106
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