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3 tera-basepairs as a fundamental limit for robust DNA replication

AuthorsMamun, Mohammed Al; Albergante, Luca; Blow, J. Julian; Newman, Thea
KeywordsDNA replication
Double fork stalls
Embryo development
Theoretical analysis
Issue Date22-Apr-2020
PublisherIOP Publishing
CitationPhysical Biology (2020)
AbstractIn order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N_U ≈ 3×10^12 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota.
Description22 p.-2 tab.
Publisher version (URL)https://doi.org/10.1088/1478-3975/ab8c2f
Appears in Collections:(CIB) Artículos
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