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Title

A fermented milk concentrate and a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides/pectin-derived acidic oligosaccharides protect suckling rats from rotavirus gastroenteritis

AuthorsRigo-Adrover, Mar; Pérez-Berezo, Teresa; Ramos Romero, Sara; van Limpt, Kees
KeywordsPrebiotics
Rotavirus
Milk
Fermented formula
Fermented milk
Issue Date28-Jan-2017
PublisherCambridge University Press
CitationBritish Journal of Nutrition 117 (2): 209-217 (2017)
AbstractHuman milk contains bioactive compounds that confer a protective role against gastrointestinal infections. In order to find supplements for an infant formula able to mimic these benefits of breast-feeding, two different concepts were tested. The products consisted of the following: (1) a Bifidobacterium breve- and Streptococcus thermophilus-fermented formula and (2) a combination of short-chain galacto-oligosaccharides/long-chain fructo-oligosaccharides with pectin-derived acidic oligosaccharides. A rotavirus infection suckling rat model was used to evaluate improvements in the infectious process and in the immune response of supplemented animals. Both nutritional concepts caused amelioration of the clinical symptoms, even though this was sometimes hidden by softer stool consistency in the supplemented groups. Both products also showed certain modulation of immune response, which seemed to be enhanced earlier and was accompanied by a faster resolution of the process. The viral shedding and the in vitro blocking assay suggest that these products are able to bind the viral particles, which can result in a milder infection. In conclusion, both concepts evaluated in this study showed interesting protective properties against rotavirus infection, which deserve to be investigated further.
Publisher version (URL)https://doi.org/10.1017/S0007114516004566
URIhttp://hdl.handle.net/10261/209687
DOI10.1017/S0007114516004566
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