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dc.contributor.authorRandazzo, Walteres_ES
dc.contributor.authorCuevas Ferrando, Enrices_ES
dc.contributor.authorSanjuán, Rafaeles_ES
dc.contributor.authorDomingo-Calap, Pilares_ES
dc.contributor.authorSánchez Moragas, Gloriaes_ES
dc.date.accessioned2020-04-29T13:22:39Z-
dc.date.available2020-04-29T13:22:39Z-
dc.date.issued2020-04-27-
dc.identifier.urihttp://hdl.handle.net/10261/209677-
dc.description.abstractBackground: The COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a rapidly emerging pandemic which has enforced extreme containment measures worldwide. In the absence of a vaccine or efficient treatment, cost-effective epidemiological surveillance strategies are urgently needed. Methods: Here, we have used RT-qPCR for SARS-CoV-2 detection in a series of longitudinal metropolitan wastewaters samples collected during the earliest stages of the epidemic in the Region of Valencia, Spain. Results: We were able to consistently detect SARS-CoV-2 RNA in samples taken when communicated cases in that region were only incipient. We also find that the wastewater viral RNA context increased rapidly and anticipated the subsequent ascent in the number of declared cases. Interpretation: Our results strongly suggest that the virus was undergoing community transmission earlier than previously believed, and show that wastewater analysis is a sensitive and cost-effective strategy for COVID-19 epidemiological surveillance. Routine implementation of this surveillance tool would significantly improve our preparedness against new or re-occurring viral outbreaks.es_ES
dc.description.sponsorshipThis research was funded by CSIC 202070E101 grant and AGL2017‐82909 (AEI/FEDER, UE) funded by Spanish Ministry of Science, Innovation and Universities to G.S. and ERC Consolidator Grant 724519‐Vis‐à‐Vis to R.S. W.R. was supported by APOSTD/2018/150 postdoctoral fellowship, and E.C‐F. was supported by a predoctoral contract from the MICINN, Call 2018.es_ES
dc.language.isoenges_ES
dc.publisherMedRxives_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/AGL2017-82909es_ES
dc.relationAGL2017-82909/AEI/10.13039/501100011033es_ES
dc.relation.isversionofPreprintes_ES
dc.rightsopenAccesses_ES
dc.titleMetropolitan Wastewater Analysis for COVID-19 Epidemiological Surveillancees_ES
dc.typepreprintes_ES
dc.identifier.doi10.1101/2020.04.23.20076679-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1101/2020.04.23.20076679es_ES
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/es_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderAgencia Estatal de Investigación (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011033es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_816bes_ES
item.openairetypepreprint-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_816b-
item.fulltextWith Fulltext-
Aparece en las colecciones: (PTI Salud Global) Colección Especial COVID-19
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