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Identification of genomic regions associated with morphological traits in Murciano-Granadina goats

AuthorsLuigi-Sierra, Maria Gracia; Landi, Vincenzo; Guan, Dailu; Delgado, Juan Vicente; Castelló, Anna ; Cabrera, Betlem; Mármol-Sánchez, Emilio; Fernández-Álvarez, Javier; Martínez, Amparo ; Such, Xavier; Jordana, A.; Amills, Marcel
KeywordsGenome-wide association
Physical trait
Goats and related species
Milk production
Issue Date2019
Citation37th International Conference on Animal Genetics (2019)
AbstractMorphological traits are of great importance to dairy goat production given their strong incidence on milk yield and longevity. However, their genomic architecture has not yet been extensively characterized. Murciano-Granadina is one of the most important goat dairy breeds in Spain, and its breeding program includes the measurement of 17 morphological traits related to udder, feet and body conformation. Our aim was to identify genomic regions associated with these 17 different morphological traits by performing a genome-wide association analysis (GWAS). A total of 722 Murciano-Granadina female goats with linear evaluation records of each morphological trait were genotyped with the Goat SNP50 BeadChip. Raw phenotypes were corrected for fixed factors (farm, age, number of births and milking stage at the scoring date). After quality control of the data, genome-wide association analyses and chromosome-wide association analyses were performed by using the genome-wide efficient mixed-model association (GEMMA) software. We found no significant associations between the typed SNPs and the studied traits at the genome-wide level. However, the chromosome-wide analysis made possible to identify 3 SNPs associated with diameter and positioning of the nipples in chromosomes 26 and 28. Interestingly, one significant SNP on chromosome 26 was located downstream the FGFBP3 gene, which modulates FGFR signaling, one of the main pathways determining the proper development of mammary stem cells. With regard to body conformation, SNPs on chromosome 17 were found to be associated with the chest width. These SNPs mapped to the genes ZNF268 and ZNF827, which encode zinc finger proteins playing important roles in cell growth, proliferation, development, apoptosis, and intracellular signal transduction. Our results suggest a strong additive polygenic background for these morphological traits since we were unable to identify any region on the genome with major effects on their phenotypic variance.
DescriptionResumen del póster presentado a la 37th International Conference on Animal Genetics (ISAG), celebrada en Lleida (España) del 7 al 12 de julio de 2019.
Appears in Collections:(CRAG) Comunicaciones congresos
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