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The impact of aging, calorie restriction and dietary fat on mitochondrial ultrastructure, dynamics and autophagy markers in mouse skeletal muscle

AuthorsGutiérrez-Casado, Elena; Khraiwesh, Husam; López-Domínguez, José A.; Montero-Guisado, Jesús; López-Lluch, Guillermo ; Navas, Plácido ; Cabo, Rafael de; Ramsey, Jon J.; González-Reyes, José A.; Villalba, José M.
KeywordsCaloric restriction
Dietary fat
Issue DateJun-2019
PublisherOxford University Press
CitationJournals of Gerontology - Series A Biological Sciences and Medical Sciences 74(6): 760-769 (2019)
AbstractLoss of skeletal muscle mass and function is a hallmark of aging. This phenomenon has been related to a dysregulation of mitochondrial function and proteostasis. Calorie restriction (CR) has been demonstrated to delay aging and preserve function until late in life, particularly in muscle. Recently, we reported the type of dietary fat plays an important role in determining life span extension with 40% CR in male mice. In these conditions, lard fed mice showed an increased longevity compared to mice fed soybean or fish oils. In this article, we analyze the effect of 40% CR on muscle mitochondrial mass, autophagy, and mitochondrial dynamics markers in mice fed these diets. In CR fed animals, lard preserved muscle fibers structure, mitochondrial ultrastructure, and fission/fusion dynamics and autophagy, not only compared to control animals, but also compared with CR mice fed soybean and fish oils as dietary fat. We focus our discussion on dietary fatty acid saturation degree as an essential predictor of life span extension in CR mice.
Publisher version (URL)http://dx.doi.org/10.1093/gerona/gly161
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