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http://hdl.handle.net/10261/209547
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Park, Soyeon V. | es_ES |
dc.contributor.author | Yang, Jae-Seong | es_ES |
dc.contributor.author | Jo, Hyesung | es_ES |
dc.contributor.author | Kang, Byunghwa | es_ES |
dc.contributor.author | Oh, Seung Soo | es_ES |
dc.contributor.author | Jung, Gyoo Yeol | es_ES |
dc.date.accessioned | 2020-04-29T07:54:51Z | - |
dc.date.available | 2020-04-29T07:54:51Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Biotechnology Advances 37(8): 107452 (2019) | es_ES |
dc.identifier.issn | 0734-9750 | - |
dc.identifier.uri | http://hdl.handle.net/10261/209547 | - |
dc.description.abstract | Ribozymes are functional RNA molecules that can catalyze biochemical reactions. Since the discovery of the first catalytic RNA, various functional ribozymes (e.g., self-cleaving ribozymes, splicing ribozymes, RNase P, etc.) have been uncovered, and their structures and mechanisms have been identified. Ribozymes have the advantage of possessing features of “RNA” molecules; hence, they are highly applicable for manipulating various biological systems. To fully employ ribozymes in a broad range of biological applications in synthetic biology, a variety of ribozymes have been developed and engineered. Here, we summarize the main features of ribozymes and the methods used for engineering their functions. We also describe the past and recent efforts towards exploiting ribozymes for effective and novel applications in synthetic biology. Based on studies on their significance in biological applications till date, ribozymes are expected to advance technologies in artificial biological systems. | es_ES |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) grant (NRF-2017R1C1B3012050) and the Global Research Laboratory Program (NRF-2016K1A1A2912829) funded by the Korea government (Ministry of Science and ICT). Also, this research was supported by Basic Science Research Program funded by the Ministry of Education (2018R1A6A3A11045727). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Ribozyme | es_ES |
dc.subject | Catalytic RNAs | es_ES |
dc.subject | Self-cleavage | es_ES |
dc.subject | Splicing | es_ES |
dc.title | Catalytic RNA, ribozyme, and its applications in synthetic biology | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.biotechadv.2019.107452 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.biotechadv.2019.107452 | es_ES |
dc.identifier.e-issn | 1873-1899 | - |
dc.contributor.funder | National Research Foundation of Korea | es_ES |
dc.contributor.funder | Ministry of Science, ICT and Future Planning (South Korea) | es_ES |
dc.contributor.funder | Government of South Korea | es_ES |
dc.contributor.funder | Ministry of Education (South Korea) | es_ES |
dc.relation.csic | No | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003725 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002701 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004083 | es_ES |
dc.identifier.pmid | 31669138 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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