English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/209490
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

AuthorsCalle, Priscila; Hotter, Georgina
KeywordsMacrophages
Diabetic nephropathy
Fibrosis
Issue Date17-Apr-2020
PublisherMultidisciplinary Digital Publishing Institute
CitationInternational Journal of Molecular Sciences 21(8): 2806 (2020)
AbstractDiabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxidative stress, inflammatory cells infiltration, inflammation and fibrosis. Macrophages (Mφ) accumulation in kidneys correlates strongly with serum creatinine, interstitial myofibroblast accumulation and interstitial fibrosis scores. However, whether or not Mφ polarization is involved in the progression of DN has not been adequately defined. The prevalence of the different phenotypes during the course of DN, the existence of hybrid phenotypes and the plasticity of these cells depending of the environment have led to inconclusive results. In the same sense the role of the different macrophage phenotype in fibrosis associated or not to DN warrants additional investigation into Mφ polarization and its role in fibrosis. Due to the association between fibrosis and the progressive decline of renal function in DN, and the role of the different phenotypes of Mφ in fibrosis, in this review we examine the role of macrophage phenotype control in DN and highlight the potential factors contributing to phenotype change and injury or repair in DN
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/ijms21082806
URIhttp://hdl.handle.net/10261/209490
DOI10.3390/ijms21082806
ISSN1661-6596
E-ISSN1422-0067
Appears in Collections:(IIBB) Artículos
Files in This Item:
File Description SizeFormat 
Macrophage_Calle_Art2020.pdf611,64 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.