English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/209475
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Incorporation of Lippia citriodora Microwave Extract into Total-Green Biogelatin-Phospholipid Vesicles to Improve Its Antioxidant Activity

AuthorsLeyva-Jiménez, Francisco Javier; Manca, Maria Letizia; Manconi, Maria; Caddeo, Carla; Vázquez, José Antonio ; Lozano-Sánchez, Jesús; Escribano-Ferrer, Elvira; Arráez-Román, David; Segura-Carretero, Antonio
KeywordsLippia citriodora
Green extract
Phospholipid vesicles
Antioxidant
Thunnus albacares
Skin delivery
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationNanomaterials 10(4): 765 (2020)
AbstractPhytochemicals from Lippia citriodora leaves were extracted by applying an innovative technology based on the use of microwaves, which represents an alternative method to extract bioactive substances. The obtained extract was incorporated into phospholipid vesicles in order to promote the antioxidant effect of the bioactive molecules present in L. citriodora extract. The extract was analyzed by High Performance Liquid Chromatography coupled to Time-Of-Flight mass spectrometer by electrospray (HPLC-ESI-TOF-MS) and different phytochemicals were detected and quantified. The whole extract was incorporated in liposomes, glycerosomes (liposomes modified with glycerol) and propylene glycol-containing vesicles (PG-PEVs). Moreover, a biopolymer obtained from fish by-product, that is Thunnus albacares skin, was added to improve the bioactivity of the formulations. The in vitro biocompatibility and the antioxidant efficacy of the extract in solution or loaded in the vesicles were tested in primary mouse embryonic fibroblasts (3T3). The results showed the superior bioactivity of the vesicle formulations over the aqueous solution of the extract, which points to an interesting strategy for the treatment of skin disorders.
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/nano10040765
URIhttp://hdl.handle.net/10261/209475
DOI10.3390/nano10040765
E-ISSN2079-4991
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Incorporation_Leyva_Art2020.pdf1,5 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.