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Title

Human PCNA Structure, Function and Interactions

AuthorsGonzález-Magaña, Amaia; Blanco, Francisco J.
KeywordsPCNA
Structure
Protein interactions
DNA sliding
Molecular recognition
DNA replication
DNA repair
Issue Date2020
PublisherMultidisciplinary Digital Publishing Institute
CitationBiomolecules 10(4): 570 (2020)
AbstractProliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with regulatory proteins through a sequence motif known as PCNA Interacting Protein box (PIP-box). We here review the latest contributions to knowledge regarding the structure-function relationships in human PCNA, particularly the mechanism of sliding, and of the molecular recognition of canonical and non-canonical PIP motifs. The unique binding mode of the oncogene p15 is described in detail, and the implications of the recently discovered structure of PCNA bound to polymerase δ are discussed. The study of the post-translational modifications of PCNA and its partners may yield therapeutic opportunities in cancer treatment, in addition to illuminating the way PCNA coordinates the dynamic exchange of its many partners in DNA replication and repair.
Description© 2020 by the authors.
Publisher version (URL)https://doi.org/10.3390/biom10040570
URIhttp://hdl.handle.net/10261/209435
DOI10.3390/biom10040570
ISSN2218-273X
E-ISSN2218-273X
Appears in Collections:(CIB) Artículos
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