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dc.contributor.authorRocha, Ana-
dc.contributor.authorGodino Gimeno, Alejandra-
dc.contributor.authorCerdá-Reverter, José Miguel-
dc.date.accessioned2020-04-28T13:15:42Z-
dc.date.available2020-04-28T13:15:42Z-
dc.date.issued2019-
dc.identifierdoi: 10.1016/bs.vh.2019.05.008-
dc.identifierissn: 0083-6729-
dc.identifier.citationVitamins and hormones 111: 1-16 (2019)-
dc.identifier.urihttp://hdl.handle.net/10261/209417-
dc.description.abstractProopiomelanocortin (POMC) belongs to the opioid/orphanin gene family whose peptide precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). In addition to POMC the family includes the proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) precursors. The opioid core sequence in POMC is incorporated by the β-endorphin that occupies the C-terminal region but this propeptide also exhibits at least two “alien” melanocortin core sequences (HFRW). An ACTH/MSH fragment merged into the opioid fragment not earlier than the two tetraploidizations of the vertebrate genome. Therefore, POMC exhibit a complex “evolutionary life” since the gene has coevolved together with two different receptor systems, i.e., opioid and melanocortin following a horse trading system. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.-
dc.languageeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.subjectPOMC-
dc.subjectMelanocortin-
dc.subjectMSH-
dc.subjectACTH-
dc.subjectβ-Endorphin-
dc.subjectOpioid-
dc.subjectEvolution-
dc.titleEvolution of proopiomelanocortin-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.1016/bs.vh.2019.05.008-
dc.relation.publisherversionhttp://dx.doi.org/10.1016/bs.vh.2019.05.008-
dc.date.updated2020-04-28T13:15:43Z-
dc.relation.csic-
dc.contributor.orcidCerdá-Reverter, José Miguel [0000-0003-1405-5750]-
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