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Title

Evolution of proopiomelanocortin

AuthorsRocha, Ana; Godino Gimeno, Alejandra; Cerdá-Reverter, José Miguel
KeywordsPOMC
Melanocortin
MSH
ACTH
β-Endorphin
Opioid
Evolution
Issue Date2019
PublisherElsevier
CitationVitamins and hormones 111: 1-16 (2019)
AbstractProopiomelanocortin (POMC) belongs to the opioid/orphanin gene family whose peptide precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). In addition to POMC the family includes the proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) precursors. The opioid core sequence in POMC is incorporated by the β-endorphin that occupies the C-terminal region but this propeptide also exhibits at least two “alien” melanocortin core sequences (HFRW). An ACTH/MSH fragment merged into the opioid fragment not earlier than the two tetraploidizations of the vertebrate genome. Therefore, POMC exhibit a complex “evolutionary life” since the gene has coevolved together with two different receptor systems, i.e., opioid and melanocortin following a horse trading system. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.
Publisher version (URL)http://dx.doi.org/10.1016/bs.vh.2019.05.008
URIhttp://hdl.handle.net/10261/209417
Identifiersdoi: 10.1016/bs.vh.2019.05.008
issn: 0083-6729
Appears in Collections:(IATS) Artículos
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