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Title

PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis

AuthorsViera, Alberto; Berenguer, Inés; Ruiz-Torres, Miguel; Gómez, Rocío; Guajardo, Andrea; Barbero, José Luis ; Losada, Ana; Suja, José A.
KeywordsAxial elements
Meiosis
Mouse
PDS5
Telomeres
Issue DateMar-2020
PublisherEMBO Press
CitationEMBO Reports e49273 (2020)
AbstractCohesin cofactors regulate the loading, maintenance, and release of cohesin complexes from chromosomes during mitosis but little is known on their role during vertebrate meiosis. One such cofactor is PDS5, which exists as two paralogs in somatic and germline cells,PDS5A and PDS5B, with unclear functions. Here, we have analyzed their distribution and functions in mouse spermatocytes. We show that simultaneous excision of Pds5A and Pds5B results in severe defects during early prophase I while their individual depletion does not, suggesting their functional redundancy. Shortened axial/lateral elements and a reduction of early recombination nodules are observed after the strong depletion of PDS5A/B proteins. Moreover,telomere integrity and their association to the nuclear envelope are severely compromised. As these defects occur without detectable reduction in chromosome-bound cohesin, we propose that the dynamic behavior of the complex, mediated by PDS5 proteins, is key for successful completion of meiotic prophase I.
Description20 p.-10 fig.
Publisher version (URL)https://doi.org/10.15252/embr.201949273
URIhttp://hdl.handle.net/10261/209393
DOI10.15252/embr.201949273
ISSN1469-221X
E-ISSN1469-3178
Appears in Collections:(CIB) Artículos
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