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Molecular mechanisms of omega3 LC-PUFA biosynthesis in marine invertebrates

AuthorsMonroig, Óscar
Issue Date20-Mar-2019
Citation8th European Workshop on Lipid Mediator (2019)
AbstractA large proportion of the biomass of marine ecosystems is represented by invertebrates, organisms primarily occupying trophic levels between primary producers (e.g. microalgae) and predators (e.g. fish). Because of their popularity as models in evolutionary developmental biology, genomic and transcriptomic sequence databases from a plethora of marine invertebrates has become available thus providing an excellent opportunity to clarify the repertoire and evolutionary history of genes of pathways of interest. Consequently, there is now strong molecular evidence showing that aquatic invertebrates possess both desaturase and elongase genes with putative roles in the biosynthesis of polyunsaturated fatty acids (PUFA). This paper reviews the current knowledge of gene complement and function of desaturases and elongases with key roles in PUFA biosynthesis of aquatic invertebrates. Three enzyme types have been examined: 1) ¿x desaturases, 2) front-end desaturases, and 3) elongases. Our data clearly shows that the phylogeny of the three enzyme families considered is more complex than initially appreciated, and that substrate specificities, particularly within desaturases, is highly unpredictable.
DescriptionTrabajo presentado en el 8th European Workshop on Lipid Mediator-Marine Lipids, celebrado en Aveiro (Portugal), el 20 de marzo de 2019
Appears in Collections:(IATS) Comunicaciones congresos
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