English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/209359
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Neuron-type specific properties of synaptic inhibition regulate hippocampal-dependent associative learning

AuthorsMéndez, Pablo
Issue Date7-Jul-2019
Citation18 Congreso de la Sociedad de Neurociencia. Santiago de Compostela 4-6 Septiembre de 2019
AbstractDespite GABAergic synapses are present in all different types of excitatory (EXC) and inhibitory hippocampal neurons (INs), it is unknown whether GABAergic synapses show neuron-type specific properties and have differential roles in learning. Here, we used Gephyrin, a scaffolding protein of inhibitory synapses, to visualize and regulate the function of inhibitory synapses in EXC neurons and INs expressing parvalbumin (PV) or somatostatin (SST). We combined fluorescence imaging and electrophysiological recordings to study the structure, function and phosphorylation-mediated regulation of inhibitory synapses in the three neuronal types. In addition, we used contextual fear conditioning protocol to determine how GABAergic synapses control the activity of the hippocampal circuits responsible for associative learning. Our results suggest a differential inhibitory control of hippocampal INs and EXC neurons through GABAergic synapses with cell-type specific regulation and roles in hippocampal dependent learning.
Description18 Congreso de la Sociedad de Neurociencia. Santiago de Compostela 4-6 Septiembre de 2019
Appears in Collections:(IC) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
SENC-PROP3-01-e1528726308102.jpg688,51 kBJPEGView/Open
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.