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Title

Neuron-type specific properties of synaptic inhibition regulate hippocampal-dependent associative learning

AuthorsMéndez, Pablo
Issue Date7-Jul-2019
Citation18 Congreso de la Sociedad de Neurociencia. Santiago de Compostela 4-6 Septiembre de 2019
AbstractDespite GABAergic synapses are present in all different types of excitatory (EXC) and inhibitory hippocampal neurons (INs), it is unknown whether GABAergic synapses show neuron-type specific properties and have differential roles in learning. Here, we used Gephyrin, a scaffolding protein of inhibitory synapses, to visualize and regulate the function of inhibitory synapses in EXC neurons and INs expressing parvalbumin (PV) or somatostatin (SST). We combined fluorescence imaging and electrophysiological recordings to study the structure, function and phosphorylation-mediated regulation of inhibitory synapses in the three neuronal types. In addition, we used contextual fear conditioning protocol to determine how GABAergic synapses control the activity of the hippocampal circuits responsible for associative learning. Our results suggest a differential inhibitory control of hippocampal INs and EXC neurons through GABAergic synapses with cell-type specific regulation and roles in hippocampal dependent learning.
Description18 Congreso de la Sociedad de Neurociencia. Santiago de Compostela 4-6 Septiembre de 2019
URIhttp://hdl.handle.net/10261/209359
Appears in Collections:(IC) Comunicaciones congresos
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