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Title

Ran GTPase expression during early development of the mouse embryo

AuthorsLópez-Casas, Pedro P. ; López-Fernández, Luis A.; Krimer, Dora B. ; Del Mazo, Jesús
KeywordsRan-GTPase
Mouse
Early embryo
Neural tissue
Hematopoietic tissue
Ectoplacental cone
Somite
Limb bud
Branchial arch
Lateral nasalprocess
Lung
Midgut
Mesonephric duct
Kidney
Issue DateApr-2002
PublisherElsevier
CitationMech Dev 113(1):103-6 (2002)
AbstractRan is a small GTP-binding protein involved in several essential roles for cell viability. This observation implies Ran might be ubiquitously expressed during development. However, Ran shows a differentiated expression pattern that is restricted to specific tissues from embryo to adult. At early embryonic stages of mouse development we found persistent Ran expression in proliferating neural tissue, neural crest derived dorsal root ganglions and sensory pits. We also showed an accumulation of Ran transcripts in main embryonic haematopoietic tissues: blood islands first and then hepatic bud. In advanced stages of development Ran is also expressed in other tissues showing a high cell turnover.
Description4 p.-4 fig.
Publisher version (URL)https://doi.org/10.1016/s0925-4773(02)00007-2
URIhttp://hdl.handle.net/10261/209008
DOI10.1016/s0925-4773(02)00007-2
ISSN0925-4773
E-ISSN1872-6356
Appears in Collections:(CIB) Artículos
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