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Title

Introduction of milk change lactic bacteria and protein metabolites in infants outgrowing cow's milk allergy

AuthorsDelgado, Susana ; Guadamuro, Lucía ; Díaz, María; Jiménez, Santiago; Molinos, Cristina; Pérez, D.; Bousoño, Carlos; Gueimonde Fernández, Miguel ; Margolles Barros, Abelardo ; Díaz, Juan José
Issue Date6-Feb-2019
Citation10th Workshop on Probiotics and Prebiotics (2019)
Abstract[Background] Cow’s milk protein allergy (CMPA) is very common in infancy. Currently, the only therapeutic option is a dairy elimination diet. Standardized oral milk challenges are performed each 6 months to determine possible tolerance adquistion. [Aim] To analyze the intestinal changes in feces of infants with non-IgE mediated CMPA after successful milk challenges and introduction of dairy product in their diet. [Methods] Twelve allergic children (between 1 and 2 years old) that were initially consuming extensively hydrolyzed formulas provided stool samples before oral milk challenges, and a week and a month after. Changes in the intestinal microbiota populations were determined by high-throughput sequencing of the 16S rRNA gene, meanwhile diverse microbial metabolites (short chain fatty acids and indoles) were quantified by chromatographic methods. [Results] The introduction of milk in infants with outgrowing non-IgE CMPA increased significantly the levels of fecal lactic acid bacteria, in particular the genus Lactococcus. Microbial metabolites derived from the catabolism of proteins, such as escatol (produced from tryptophan) enhanced, meanwhile branched chain fatty acids diminished. [Conclusions]: The introduction of dairy products is accompanied by modifications in the infant gut environment through changes in the microbiota and protein metabolic end-products according to this kind of dietary change.
DescriptionTrabajo presentado en el 10th Workshop on Probiotics and Prebiotics, de la Sociedad Española de Probióticos y Prebióticos (SEPyP), celebrado en Las Palmas de Gran Canarias, del 6 al 8 de febrero de 2019
URIhttp://hdl.handle.net/10261/208987
Appears in Collections:(IPLA) Comunicaciones congresos
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