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Self-Assembly of Nanoparticle-Spiked Pillar Arrays for Plasmonic Biosensing

AuthorsPark, S.G.; Xiao, X.; Min, J.; Mun, C.W.; Jung, H.S.; Giannini, V. ; Weissleder, R.; Maier, S.A.; Im, H.; Kim, D.H.
Keywords3D nanostructures
Plasmonic biosensors
Spherical metal nanoparticles
Surface diffusion
Surface energy
Issue Date29-Aug-2019
CitationAdvanced Functional Materials 29: 1904257 (2019)
AbstractPlasmonic biosensors have demonstrated superior performance in detecting various biomolecules with high sensitivity through simple assays. Scaled-up, reproducible chip production with a high density of hotspots in a large area has been technically challenging, limiting the commercialization and clinical translation of these biosensors. A new fabrication method for 3D plasmonic nanostructures with a high density, large volume of hotspots and therefore inherently improved detection capabilities is developed. Specifically, Au nanoparticle-spiked Au nanopillar arrays are prepared by utilizing enhanced surface diffusion of adsorbed Au atoms on a slippery Au nanopillar arrays through a simple vacuum process. This process enables the direct formation of a high density of spherical Au nanoparticles on the 1 nm-thick dielectric coated Au nanopillar arrays without high-temperature annealing, which results in multiple plasmonic coupling, and thereby large effective volume of hotspots in 3D spaces. The plasmonic nanostructures show signal enhancements over 8.3 × 10-fold for surface-enhanced Raman spectroscopy and over 2.7 × 10-fold for plasmon-enhanced fluorescence. The 3D plasmonic chip is used to detect avian influenza-associated antibodies at 100 times higher sensitivity compared with unstructured Au substrates for plasmon-enhanced fluorescence detection. Such a simple and scalable fabrication of highly sensitive 3D plasmonic nanostructures provides new opportunities to broaden plasmon-enhanced sensing applications.
Description9 pags. 5 figs.
Publisher version (URL)http://dx.doi.org/10.1002/adfm.201904257
Identifiersdoi: 10.1002/adfm.201904257
issn: 1616-3028
Appears in Collections:(CFMAC-IEM) Artículos
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