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Title

A topological view of the replicon

AuthorsSchvartzman, Jorge Bernardo ; Stasiak, Andrzej Z.
KeywordsReplication
Plasmid
Supercoiling
Catenane
Knot
Issue DateMar-2004
PublisherEMBO Press
CitationEMBO Rep 5(3):256-61 (2004)
AbstractThe replication of circular DNA faces topological obstacles that need to be overcome to allow the complete duplication and separation of newly replicated molecules. Small bacterial plasmids provide a perfect model system to study the interplay between DNA helicases, polymerases, topoisomerases and the overall architecture of partially replicated molecules. Recent studies have shown that partially replicated circular molecules have an amazing ability to form various types of structures (supercoils, precatenanes, knots and catenanes) that help to accommodate the dynamic interplay between duplex unwinding at the replication fork and DNA unlinking by topoisomerases.
Description6 p.-3 fig.
Publisher version (URL)https://doi.org/10.1038/sj.embor.7400101
URIhttp://hdl.handle.net/10261/208669
DOI10.1038/sj.embor.7400101
ISSN1469-221X
E-ISSN1469-3178
Appears in Collections:(CIB) Artículos
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