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Title

Functionalization of gold nanoparticles with peptidomimetics as a targeted therapy for multiple sclerosis

AuthorsRamírez-Jiménez, Rafael; Quagliarini, Erica; Bussolari, Francesca; Asín, Laura; Martín-Rapún, Rafael; Gentilucci, Luca; Fuente, Jesús M. de la
Issue Date2019
Citation2nd Spanish Conference on Biomedical Applications of Nanomaterials (2019)
AbstractMultiple Sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system that can lead to severe disability. The wide variety of symptoms characteristic for MS such as numbness, weakness, paresis, visual problems, severe fatigue and depression and also intellectual and cognitive impairments are caused by by brain and spinal cord's inflammation that damages the myelin sheath. During the last years, significant progress has been made in understanding how pathogenic leukocytes migrate from the periphery to the CNS, and the critical roles played by the α4ß1and α4ß7 integrins have been studied extensively in animal models, and in patients in clinical trials. Thus, the counter ligands of these integrins (VCAM1 and MAdCAM1) are a perfect target to prevent the inflammatory process. Gold nanoparticles (AuNPs) show low toxicity and excellent optical properties, they represent a very powerful tool in imaging and therapy applications. In this work, we propose the functionalization of AuNPs with five different integrins ligand-like peptidomimetics to target the pathogenic leukocytes and create a challenging device for imaging and therapy of MS. Preliminary outcomes in in vitro experiments will be presented in order to lay the foundations for future study.
DescriptionPóster presentado a la 2nd Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), celebrada en Madrid del 6 al 7 de junio de 2019.
URIhttp://hdl.handle.net/10261/208645
Appears in Collections:(ICMA) Comunicaciones congresos
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