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Title

First aromatic amine organocatalysed activation of α,β-unsaturated ketones

AuthorsSonsona, Isaac G.; Marqués-López, Eugenia ; Gimeno, M. Concepción ; Herrera, Raquel P.
Issue Date16-Jul-2019
PublisherRoyal Society of Chemistry (UK)
CitationNew Journal of Chemistry 43(31): 12233-12240 (2019)
AbstractThis work provides an unprecedented example of a chiral aromatic amine used to activate α,β-unsaturated ketones in asymmetric aminocatalysis. Chiral aromatic diamine VII has been efficiently employed, as a proof of concept, in the Michael addition reaction between benzylideneacetones (1a-f) and coumarins (2a-d). The reaction gives rise to warfarin derivatives 3 with promising results using this family of catalysts for the first time. The additional studies performed supported the bifunctional mode of activation of the chiral catalyst VII and the covalent nature of the interactions between the catalyst VII and benzylideneacetones 1.
Publisher version (URL)http://doi.org/10.1039/c9nj02392e
URIhttp://hdl.handle.net/10261/208612
Identifiersdoi: 10.1039/c9nj02392e
e-issn: 1369-9261
issn: 1144-0546
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