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In vivo comparison of the biodistribution and long-term fate of colloids – gold nanoprisms and nanorods – with minimum surface modification
|Authors:||Alfranca, Gabriel; Beola, Lilianne; Liu, Yanlei; Gutiérrez, Lucía ; Zhang, Amin; Artiga, Álvaro; Cui, Daxiang; Fuente, Jesús M. de la|
|Citation:||Nanomedicine 14(23): 3035-3055 (2019)|
|Abstract:||[Aim]: To study the difference in biodistribution of gold nanoprisms (NPr) and nanorods (NR), PEGylated to ensure colloidal stability.|
[Materials & methods]: Surface changes were studied for nanoparticles in different media, while the biodistribution was quantified and imaged in vivo.
[Results]: Upon interaction with the mouse serum, NR showed more abrupt changes in surface properties than NPr. In the in vivo tests, while NPr accumulated similarly in the spleen and liver, NR showed much higher gold presence in the spleen than in liver; together with some accumulation in kidneys, which was nonexistent in NPr. NPr were cleared from the tissues 2 months after administration, while NR were more persistent.
[Conclusion]: The results suggest that the differential biodistribution is caused by size-/shape-dependent interactions with the serum.
|Publisher version (URL):||https://doi.org/10.2217/nnm-2019-0253|
|Appears in Collections:||(ICMA) Artículos|