English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/207984
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:


Effect of spin clustering on basic and relaxometric properties of magnetic nanoparticles

AuthorsArosio, P.; Basini, M.; Barbaglia, A.; Piñol, Rafael; Murillo, José Luis; Millán, Ángel ; Lascialfari, A.
KeywordsBiomedical applications
Magnetic nanoparticles
Spin topology
Issue Date2019
PublisherIngenta Connet
CitationJournal of Nanoscience and Nanotechnology 19(5): 2950-2962 (2019)
AbstractAn increasing awareness about novel medical applications of smaller, inorganic-based nanoparticles, possessing unique properties at the nanoscale, has led to a burst of research activities in the development of “nanoprobes” for diagnostic medicine and agents for novel, externally activated therapies. In this research field magnetic nanoparticles are prominent due to fundamental peculiar properties particularly appealing for their use in materials and biomedical applications. Aiming to study the relationship between the topology of the magnetic nanoparticles and their efficacy as MRI contrast agents (relaxometric properties), we prepared three different stable colloidal suspension (ferrofluid) of magnetic nanobeads (MNBs) constituted by a discrete number of maghemite nanoparticles, arranged in disordered clusters or ordered in a polymeric matrix. An accurate morpho-dimensional and magnetic characterization displays the close correlation between the magnetic fundamental properties and the topology of our spin systems. The NMR relaxometry profiles confirmed the nature of the physical mechanisms inducing the increase of nuclear relaxation rates at low (magnetic anisotropy) and high (Curie relaxation) magnetic fields. Moreover the transverse relaxivity (r 2) values for all the MNBs are higher than those of common contrast agents and the differences between the three MNBs are suggested to be due to the spin topology effect.
Publisher version (URL)https://doi.org/10.1166/jnn.2019.16019
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
2018 Arosio JNN.pdf545,36 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.