English
español
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/207977
Share/Impact:
Statistics |
![]() ![]() ![]() |
|
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |||
|
Title: | Evidence for progressive microstructural damage in early multiple sclerosis by multi-shell diffusion magnetic resonance imaging |
Authors: | Toschi, Nicola; Santis, Silvia de; Granberg, Tobias; Ouellette, Russell; Treaba, Constantina A.; Herranz, Elena; Mainero, Caterina |
Keywords: | Multiple sclerosis Multi-shell diffusion MRI Axonal pathology Normal-appearing white matter CHARMED model Longitudinal disease progression |
Issue Date: | 1-Apr-2019 |
Publisher: | Elsevier |
Citation: | Neuroscience 403: 27-34 (2019) |
Abstract: | In multiple sclerosis (MS), it would be of clinical value to be able to track the progression of axonal pathology, especially before the manifestation of clinical disability. However, non-invasive evaluation of short-term longitudinal progression of white matter integrity is challenging. This study aims at assessing longitudinal changes in the restricted (i.e. intracellular) diffusion signal fraction (FR) in early-stage MS by using ultra-high gradient strength multi-shell diffusion magnetic resonance imaging. In 11 early MS subjects (disease duration ≤ 5 years), FR was obtained at two timepoints (one year apart) through the Composite Hindered and Restricted Model of Diffusion, along with conventional Diffusion Tensor Imaging metrics. At follow-up, no statistically significant change was detected in clinical variables, while all imaging metrics showed statistically significant longitudinal changes (p < 0.01, corrected for multiple comparisons) in widespread regions in normal-appearing white matter (NAWM). The most extensive longitudinal changes were observed in FR, including areas known to include a large fraction of crossing fibers. Furthermore, FR was also the only metric showing significant longitudinal changes in lesions that were present at both time points (p = 0.007), with no significant differences found for conventional diffusion metrics. Finally, FR was the only diffusion metric (as compared to Diffusion Tensor Imaging) that revealed pre-lesional changes already present at baseline. Taken together, our data provide evidence for progressive microstructural damage in the NAWM of early MS cases detectable already at 1-year follow-up. Our study highlights the value of multi-shell diffusion imaging for sensitive tracking of disease evolution in MS before any clinical changes are observed. |
Description: | This article is part of a Special Issue entitled: SI: MRI and Neuroinflammation. |
Publisher version (URL): | https://doi.org/10.1016/j.neuroscience.2019.01.022 |
URI: | http://hdl.handle.net/10261/207977 |
DOI: | 10.1016/j.neuroscience.2019.01.022 |
ISSN: | 0306-4522 |
Appears in Collections: | (IN) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Manuscript_MS_Followup_revised_final.pdf | 517,03 kB | Adobe PDF | ![]() View/Open |
Show full item record
Review this work
Review this work
Related articles:
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.