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Aluminum translocation to the central nervous system of sheep repetitively inoculated with aluminum-adjuvants

AuthorsMiguel, Ricardo de; Asín, Javier; Rodríguez-Largo, Ana; Molín, Jéssica; Echeverría, Irache; Pablo, Lorena de ; Andrés, Damián F. de ; Mold, Matthew; Pérez, Marta M.; Reina, Ramsés ; Luján, Lluís
Issue DateJan-2020
PublisherElsevier BV
CitationJournal of Comparative Pathology 174: 185 (2020)
AbstractOvine management systems usually involve prophylactic vaccination. Most ovine vaccines use aluminium hydroxide as adjuvant. In sheep, aluminium hydroxide promotes an effective immune response, but also induces local granulomatous reactions at the injection site. Aluminium can reach the regional lymph node. The aim of this work was to describe the translocation of subcutaneously inoculated aluminium-based adjuvants to the central nervous system (CNS).
DescriptionTrabajo presentado en el Joint Congress of the Veterinary Pathology and Veterinary Clinical Pathology, celebrado en Arnhem (Países Bajos), del 25 al 28 de septiembre de 2019
Publisher version (URL)https://doi.org/10.1016/j.jcpa.2019.10.149
Identifiersdoi: 10.1016/j.jcpa.2019.10.149
issn: 0021-9975
Appears in Collections:(IDAB) Comunicaciones congresos
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