Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/207573
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Cellular heterogeneity results from indirect effects under metabolic tradeoffs |
Autor: | Ollé-Vila, Aina CSIC ORCID; Solé, Ricard V. CSIC ORCID | Palabras clave: | Mutualism heterogeneity Synthetic biology Biofilms Multicellularity |
Fecha de publicación: | 25-sep-2019 | Editor: | Royal Society of Chemistry (UK) | Citación: | Royal Society Open Science 6(9): 190281 (2019) | Resumen: | The emergence and maintenance of multicellularity requires the coexistence of diverse cellular populations displaying cooperative relationships. This enables long-term persistence of cellular consortia, particularly under environmental constraints that challenge cell survival. Toxic environments are known to trigger the formation of multicellular consortia capable of dealing with waste while promoting cell diversity as a way to overcome selection barriers. In this context, recent theoretical studies suggest that an environment containing both resources and toxic waste can promote the emergence of complex, spatially distributed proto-organisms exhibiting division of labour and higher-scale features beyond the cell–cell pairwise interactions. Some previous non-spatial models suggest that the presence of a growth inhibitor can trigger the coexistence of competitive species in an antibiotic-resistance context. In this paper, we further explore this idea using both mathematical and computational models taking the most fundamental features of the proto-organisms model interactions. It is shown that this resource-waste environmental context, in which both species are lethally affected by the toxic waste and metabolic tradeoffs are present, favours the maintenance of diverse populations. A spatial, stochastic extension confirms our basic results. The evolutionary and ecological implications of these results are outlined. | Versión del editor: | http://doi.org/10.1098/rsos.190281 | URI: | http://hdl.handle.net/10261/207573 | DOI: | 10.1098/rsos.190281 | Identificadores: | doi: 10.1098/rsos.190281 e-issn: 2054-5703 |
Aparece en las colecciones: | (IBE) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
cellular_heterogeneity_indirect_effects.pdf | 906,77 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
165
checked on 23-abr-2024
Download(s)
123
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons