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http://hdl.handle.net/10261/207543
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dc.contributor.author | Ortega, Pedro | - |
dc.contributor.author | Gómez-González, Belén | - |
dc.contributor.author | Aguilera, Andrés | - |
dc.date.accessioned | 2020-04-14T13:11:46Z | - |
dc.date.available | 2020-04-14T13:11:46Z | - |
dc.date.issued | 2019-11-15 | - |
dc.identifier | doi: 10.1038/s41467-019-13210-5 | - |
dc.identifier | e-issn: 2041-1723 | - |
dc.identifier.citation | Nature Communications 10: 5178 (2019) | - |
dc.identifier.uri | http://hdl.handle.net/10261/207543 | - |
dc.description.abstract | Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, lead to double strand breaks (DSBs), which are preferentially repaired by sister-chromatid recombination (SCR). To decipher the role of chromatin in eukaryotic DSB repair, here we analyze a collection of yeast chromatin-modifying mutants using a previously developed system for the molecular analysis of repair of replication-born DSBs by SCR based on a mini-HO site. We confirm the candidates through FLP-based systems based on a mutated version of the FLP flipase that causes nicks on either the leading or lagging DNA strands. We demonstrate that Rpd3L and Hda1 histone deacetylase (HDAC) complexes contribute to the repair of replication-born DSBs by facilitating cohesin loading, with no effect on other types of homology-dependent repair, thus preventing genome instability. We conclude that histone deacetylation favors general sister chromatid cohesion as a necessary step in SCR. | - |
dc.description.sponsorship | Research was supported by the European Research Council (ERC2014 AdG669898 TARLOOP), the Spanish Ministry of Economy and Competitiveness (BFU2016-75058-P), and the European Union (FEDER). P.O. was supported by a predoctoral training grant from the Spanish Ministry of Economy and Competitiveness and B.G.-G. by the Spanish Association Against Cancer (AECC). | - |
dc.language | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75058-P | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | DNA recombination | - |
dc.subject | Genomic instability | - |
dc.subject | Homologous recombination | - |
dc.title | Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/s41467-019-13210-5 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/s41467-019-13210-5 | - |
dc.date.updated | 2020-04-14T13:11:46Z | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | European Research Council | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Asociación Española Contra el Cáncer | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 31729385 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Rpd3L_Ortega.pdf | 2,21 MB | Adobe PDF | Visualizar/Abrir |
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