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Título: | Self-defense of macrophages against oxidative injury: Fighting for their own survival |
Autor: | Virág, László; Jaén, Rafael I. CSIC ORCID; Regdon, Zsolt; Boscá, Lisardo CSIC ORCID CVN ; Prieto, Patricia CSIC ORCID | Palabras clave: | Inflammation Immunity Macrophage Oxidative burst Metabolism Apoptosis Parthanatos PARP1 NRF2 HO-1 FoxO Antioxidants Eicosanoids Specialized pro-resolving mediators Senescence Aging |
Fecha de publicación: | oct-2019 | Editor: | Elsevier | Citación: | Redox Biology 26: 101261 (2019) | Resumen: | Activated macrophages play a central role in both the development and resolution of inflammation. These immune cells need to be functional in harmful conditions with high levels of reactive oxygen and nitrogen species that can damage their basic cell components, which may alter their metabolism. An excessive accumulation of these cell alterations drives macrophages inexorably to cell death, which has been associated to the development of several inflammatory diseases and even with aging in a process termed as “immunosenescence”. Macrophages, however, exhibit a prolonged survival in this hostile environment because they equip themselves with a complex network of protective mechanisms. Here we provide an overview of these self-defense mechanisms with special attention being paid to bioactive lipid mediators, NRF2 signaling and metabolic reprogramming. | Versión del editor: | http://dx.doi.org/10.1016/j.redox.2019.101261 | URI: | http://hdl.handle.net/10261/207442 | DOI: | 10.1016/j.redox.2019.101261 | ISSN: | 2213-2317 | E-ISSN: | 2213-2317 |
Aparece en las colecciones: | (IIBM) Artículos |
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Self_defense_Virag_Art2019.pdf | 1,56 MB | Adobe PDF | Visualizar/Abrir |
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