Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/207049
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Association between the pig genome and its gut microbiota composition |
Autor: | Crespo-Piazuelo, Daniel CSIC ORCID; Migura-García, Lourdes CSIC ORCID; Estellé, Jordi; Criado-Mesas, Lourdes CSIC ORCID; Revilla, Manuel CSIC ORCID; Castelló, Anna CSIC ORCID; Muñoz, María; García-Casco, Juan M.; Fernández, Ana Isabel; Ballester, María CSIC ORCID; Folch, Josep María CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Springer Nature | Citación: | Scientific Reports 9: 8791 (2019) | Resumen: | The gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess the role of the host genome in the modulation of the microbiota composition in pigs. Gut microbiota compositions were estimated through sequencing the V3-V4 region of the 16S rRNA gene from rectal contents of 285 pigs. A total of 1,261 operational taxonomic units were obtained and grouped in 18 phyla and 101 genera. Firmicutes (45.36%) and Bacteroidetes (37.47%) were the two major phyla obtained, whereas at genus level Prevotella (7.03%) and Treponema (6.29%) were the most abundant. Pigs were also genotyped with a high-throughput method for 45,508 single nucleotide polymorphisms that covered the entire pig genome. Subsequently, genome-wide association studies were made among the genotypes of these pigs and their gut microbiota composition. A total of 52 single-nucleotide polymorphisms distributed in 17 regions along the pig genome were associated with the relative abundance of six genera; Akkermansia, CF231, Phascolarctobacterium, Prevotella, SMB53, and Streptococcus. Our results suggest 39 candidate genes that may be modulating the microbiota composition and manifest the association between host genome and gut microbiota in pigs. | Versión del editor: | https://doi.org/10.1038/s41598-019-45066-6 | URI: | http://hdl.handle.net/10261/207049 | DOI: | 10.1038/s41598-019-45066-6 | E-ISSN: | 2045-2322 |
Aparece en las colecciones: | (CRAG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
associaticomposi.pdf | 1,92 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
36
checked on 17-abr-2024
SCOPUSTM
Citations
53
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
46
checked on 26-feb-2024
Page view(s)
125
checked on 19-abr-2024
Download(s)
218
checked on 19-abr-2024