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Título: | Postprandial triglyceride-rich lipoproteins promote lipid accumulation and apolipoprotein B-48 receptor transcriptional activity in human circulating and murine bone marrow neutrophils in a fatty acid-dependent manner |
Autor: | Ortega-Gómez, Almudena; Varela, Lourdes CSIC ORCID; López Martín, Sergio ; Montserrat-de la Paz, Sergio CSIC ORCID; Sánchez, Rosario CSIC ORCID ; Muriana, Francisco J. G. CSIC ORCID ; Bermúdez, Beatriz CSIC ORCID; Abia, Rocío CSIC ORCID | Palabras clave: | Atherosclerosis Bone marrow MUFAs Neutrophils Omega-3 PUFAs Postprandial triglyceride-rich lipoproteins Saturated fatty acids |
Fecha de publicación: | 2017 | Editor: | John Wiley & Sons | Citación: | Molecular Nutrition and Food Research 61 (9): 1600879 (2017) | Resumen: | Scope: Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in atherosclerosis. We elucidated how the acute administration of MUFAs, omega-3 PUFAs and saturated fatty acids (SFAs) affects human circulating and murine BM neutrophil lipid accumulation and functionality. Methods and results: Postprandial hypertriglyceridemia was induced in healthy subjects and Apoe¿/¿ mice by the acute administration of dietary fats enriched in MUFAs, PUFAs or SFAs. Postprandial hypertriglyceridemia increased apolipoprotein-B48 receptor (ApoB48R) transcriptional activity that was linearly correlated with intracellular TGs accumulation in human circulating and murine BM neutrophils. MUFA and omega-3 PUFAs attenuated ApoB48R gene expression and intracellular TG accumulation compared to SFAs. TRLs induced apoB48R-dependent TG accumulation in human neutrophils ex-vivo. Murine BM neutrophils showed a decrease in surface L-selectin and an increase in TNF-¿ and IL-1ß mRNA expressions only after SFAs administration. TRLs enriched in SFAs induced BM neutrophil degranulation ex-vivo suggesting cell priming/activation. Conclusion: Postprandial TRLs disrupts the normal biology and function of circulating and BM neutrophils. MUFA- and omega-3 PUFA-rich dietary fats such as virgin olive oil or fish oil has the potential to prevent excessive neutrophil lipid accumulation and activation by targeting the fatty acid composition of TRLs. | Descripción: | 5 Figuras.-- 1 Tabla | Versión del editor: | http://dx.doi.org/10.1002/mnfr.201600879 | URI: | http://hdl.handle.net/10261/206942 | DOI: | 10.1002/mnfr.201600879 | Identificadores: | doi: 10.1002/mnfr.201600879 issn: 1613-4133 |
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