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dc.contributor.authorPuttaraksa, G.-
dc.contributor.authorMuceli, S.-
dc.contributor.authorGallego, Juan Álvaro-
dc.contributor.authorHolobar, Ales-
dc.contributor.authorCharles, S.K.-
dc.contributor.authorPons Rovira, José Luis-
dc.contributor.authorFarina, Dario-
dc.identifierdoi: 10.1152/jn.00407.2019-
dc.identifierissn: 1522-1598-
dc.identifier.citationJournal of Neurophysiology 122: 2043- 2053 (2019)-
dc.description.abstractPathological tremor is an oscillation of body parts at 3-10 Hz, determined by the output of spinal motor neurons (MNs), which receive synaptic inputs from supraspinal centers and muscle afferents. The behavior of spinal MNs during tremor is not well understood, especially in relation to the activation of the multiple muscles involved. Recent studies on patients with essential tremor have shown that antagonist MN pools receive shared input at the tremor frequency. In this study, we investigated the synaptic inputs related to tremor and voluntary movement, and their coordination across antagonist muscles. We analyzed the spike trains of motor units (MUs) identified from high-density surface electromyography from the forearm extensor and flexor muscles in 15 patients with essential tremor during postural tremor. The shared synaptic input was quantified by coherence and phase difference analysis of the spike trains. All pairs of spike trains in each muscle showed coherence peaks at the voluntary drive frequency (1-3 Hz, 0.2 ± 0.2, mean ± SD) and tremor frequency (3-10 Hz, 0.6 ± 0.3) and were synchronized with small phase differences (3.3 ± 25.2° and 3.9 ± 22.0° for the voluntary drive and tremor frequencies, respectively). The coherence between MN spike trains of antagonist muscle groups at the tremor frequency was significantly smaller than intramuscular coherence. We predominantly observed in-phase activation of MUs between agonist/antagonist muscles at the voluntary frequency band (0.6 ± 48.8°) and out-of-phase activation at the tremor frequency band (126.9 ± 75.6°). Thus MNs innervating agonist/antagonist muscles concurrently receive synaptic inputs with different phase shifts in the voluntary and tremor frequency bands.NEW & NOTEWORTHY Although the mechanical characteristics of tremor have been widely studied, the activation of the affected muscles is still poorly understood. We analyzed the behavior of motor units of pairs of antagonistic wrist muscle groups in patients with essential tremor and studied their activity at voluntary movement- and tremor-related frequencies. We found that the phase relation between inputs to antagonistic muscles is different at the voluntary and tremor frequency bands.-
dc.description.sponsorshipThis study was supported by European Projects EXTEND Grant H2020-ICT-23-2017-779982 and NeuroTREMOR Grant ICT-2011.5.1-287739. G.Puttaraksa was supported by the Royal Thai Government Scholarship. J. A.Gallego received funding from Community of Madrid Atracción de Talento Grant 2017-T2/TI C-5263. A. Holobar was supported by Slovenian Research Agency Program Funding P2-0041 and Projects J2-7357 and L7-9421.-
dc.publisherAmerican Physiological Society-
dc.relation.isversionofPublisher's version-
dc.subjectessential tremor-
dc.subjectmotor units-
dc.subjectneural drive-
dc.subjectvoluntary control-
dc.titleVoluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients-
dc.contributor.funderEuropean Commission-
dc.contributor.funderRoyal Thai Government-
dc.contributor.funderComunidad de Madrid-
dc.contributor.funderSlovenian Research Agency-
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