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dc.contributor.authorCusters, Renées_ES
dc.contributor.authorCasacuberta, Josep M.es_ES
dc.contributor.authorEriksson, Dennises_ES
dc.contributor.authorSági, Lászlóes_ES
dc.contributor.authorSchiemann, Joachimes_ES
dc.date.accessioned2020-04-05T19:22:51Z-
dc.date.available2020-04-05T19:22:51Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Bioengineering and Biotechnology 6: 213 (2019)es_ES
dc.identifier.urihttp://hdl.handle.net/10261/206517-
dc.description.abstractThe ability to successfully exploit genome edited organisms for the benefit of food security and the environment will essentially be determined by the extent to which these organisms fall under specific regulatory provisions. In many jurisdictions the answer to this question is considered to depend on the genetic characteristics of the edited organism, and whether the changes introduced in its genome do (or do not) occur naturally. We provide here a number of key considerations to assist with this evaluation as well as a guide of concrete examples of genetic alterations with an assessment of their natural occurrence. These examples support the conclusion that for many of the common types of alterations introduced by means of genome editing, the resulting organisms would not be subject to specific biosafety regulatory provisions whenever novelty of the genetic combination is a crucial determinant.es_ES
dc.description.sponsorshipThis work was supported by the Swedish Foundation for Strategic Environmental Research (Mistra) through the Mistra Biotech research program.es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleGenetic alterations that do or do not occur naturally; consequences for genome edited organisms in the context of regulatory oversightes_ES
dc.typeartículoes_ES
dc.identifier.doihttp://dx.doi.org/10.3389/fbioe.2018.00213-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fbioe.2018.00213es_ES
dc.identifier.e-issn2296-4185-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderSwedish Foundation for Strategic Researches_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.pmid30701172-
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