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dc.contributor.authorMartí, J. M.-
dc.contributor.authorFernández-Cortés, Mónica-
dc.contributor.authorSerrano-Sáenz, Santiago-
dc.contributor.authorZamudio-Martínez, Esteban-
dc.contributor.authorDelgado-Bellido, Daniel-
dc.contributor.authorGarcía-Díaz, Ángel-
dc.contributor.authorOliver, Francisco Javier-
dc.date.accessioned2020-03-27T13:24:13Z-
dc.date.available2020-03-27T13:24:13Z-
dc.date.issued2020-
dc.identifier.citationCancers 12(3): 739 (2020)-
dc.identifier.urihttp://hdl.handle.net/10261/205578-
dc.description© 2020 by the authors.-
dc.description.abstractPoly(ADP-ribose) polymerases (PARPs), represent a family of 17 proteins implicated in a variety of cell functions; some of them possess the enzymatic ability to synthesize and attach poly (ADP-ribose) (also known as PAR) to different protein substrates by a post-translational modification; PARPs are key components in the cellular response to stress with consequences for different physiological and pathological events, especially during neoplasia. In recent years, using PARP inhibitors as antitumor agents has raised new challenges in understanding their role in tumor biology. Notably, the function of PARPs and PAR in the dynamic of tumor microenvironment is only starting to be understood. In this review, we summarized the conclusions arising from recent studies on the interaction between PARPs, PAR and key features of tumor microenvironment such as hypoxia, autophagy, tumor initiating cells, angiogenesis and cancer-associated immune response.-
dc.description.sponsorshipThis work was supported by Ministerio de Economía y Competividad, Spanish Ministry of Economy and Competitiveness SAF2012-40011-C02-01, SAF2015-70520-R, RTICC RD12/0036/0026, RTI2018-098968-B-I00, CIBER Cáncer ISCIII CB16/12/00421 and Fundación Domingo Martínez to FJO. JMMC, is recipient of a FPI fellowship from Spanish Ministerio de Ciencia; MFC and EZM are recipients of FPU fellowships from the Spanish Ministerio de Ciencia.-
dc.language.isoeng-
dc.publisherMultidisciplinary Digital Publishing Institute-
dc.relationMINECO/ICTI2013-2016/SAF2015-70520-R-
dc.relationMICIU/ICTI2017-2020/RTI2018-098968-B-I00-
dc.relationRTI2018-098968-B-I00/AEI/10.13039/501100011033-
dc.relation.isversionofPublisher’s version-
dc.rightsopenAccess-
dc.subjectTumor microenvironment-
dc.subjectPARPs-
dc.subjectPARylation-
dc.subjectHypoxia-
dc.subjectAutophagy-
dc.subjectPARP inhibitors-
dc.titleThe Multifactorial Role of PARP-1 in Tumor Microenvironment-
dc.typeartículo-
dc.identifier.doihttp://dx.doi.org/10.3390/cancers12030739-
dc.description.peerreviewedPeer reviewed-
dc.relation.publisherversionhttps://doi.org/10.3390/cancers12030739-
dc.identifier.e-issn2072-6694-
dc.date.updated2020-03-27T13:24:13Z-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderFundación Domingo Martínez-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
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