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Generation of an integration-free iPSC line, ICCSICi006-A, derived from a male Alzheimer's disease patient carrying the PSEN1-G206D mutation

AuthorsDíaz-Guerra, Eva CSIC ORCID; Oria-Muriel, M.A.; Moreno-Jiménez, E.P.; Rodríguez-Travera, Eva; Orera, M.; Hernandez, Isabel; Ruiz A.; Vicario, C.
Issue Date2019
CitationStem Cell Research 40: 1- 6 (2019)
AbstractThe familial form of Alzheimer's disease (FAD), which is caused by mutations in PRESENILIN 1 (PSEN1) and amyloid precursor protein (APP) genes, represents less than 5% of all AD cases and has an early-onset. We report the generation and characterization of an iPSC line derived from a FAD patient carrying the PSEN1-G206D mutation. The iPSC line maintained the original genotype, a normal karyotype, was free from Sendai viral vectors and reprogramming factors (OCT4, SOX2, KLF4 and c-MYC), presented a typical morphology, expressed endogenous pluripotency markers, and could be differentiated into ectodermal, mesodermal and endodermal cells, confirming its pluripotency.
Publisher version (URL)http://dx.doi.org/10.1016/j.scr.2019.101574
Identifiersdoi: 10.1016/j.scr.2019.101574
issn: 1876-7753
Appears in Collections:(IC) Artículos
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