Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/204824
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | In vitro and in vivo testing of the hypocholesterolemic activity of ergosterol- and β-glucan-enriched extracts obtained from shiitake mushrooms (Lentinula edodes) |
Autor: | Morales, Diego CSIC ORCID ; Tejedor-Calvo, Eva CSIC ORCID; Jurado-Chivato, Noelia CSIC; Polo, Gonzalo; Tabernero, María CSIC; Ruiz-Rodríguez, Alejandro CSIC ; Largo, Carlota; Soler-Rivas, Cristina CSIC ORCID | Fecha de publicación: | 2019 | Editor: | Royal Society of Chemistry (UK) | Citación: | Food and Function 10(11): 7325-7332 (2019) | Resumen: | Herein, a supercritical extraction plant (with a 6 L extraction cell) was successfully used to obtain ergosterol-enriched extracts from Lentinula edodes under the following conditions: a temperature of 40 °C, pressure of 225 bar, reaction time of 1–5 h, and the flow rate of 20 L h−1 for recirculated CO2. Moreover, ergosterol (ERG) and the SFE extract (SFE) with highest ergosterol concentration were microemulsified and submitted to in vitro digestion to study their ability to displace cholesterol from dietary mixed micelles (DMMs). ERG was also mixed with a β-glucan-enriched (33.5%) extract (BGE) obtained from L. edodes to investigate the synergies between them; the results indicated that all these extracts (including BGE without ERG) could reduce the cholesterol levels in the DMMs. However, when ERG and SFE were simultaneously administered to mice with a hypercholesterolemic diet, no significant differences in the serum cholesterol levels were detected as compared to the case of the control. However, when only BGE was administrated to another mice model previously induced with hypercholesterolemia, significant reduction in the cholesterol levels was noticed. | Versión del editor: | https://doi.org/10.1039/C9FO01744E | URI: | http://hdl.handle.net/10261/204824 | DOI: | 10.1039/C9FO01744E | ISSN: | 2042-6496 | E-ISSN: | 2042-650X |
Aparece en las colecciones: | (CIAL) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
DiegoMorales2.pdf | 355,12 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
WEB OF SCIENCETM
Citations
27
checked on 26-feb-2024
Page view(s)
199
checked on 18-mar-2024
Download(s)
4
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.