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Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

AuthorsSabater, Carlos CSIC ORCID ; Molina-Tijeras, Jose Alberto; Vezza, Teresa; Corzo, Nieves CSIC ORCID ; Montilla, Antonia CSIC ORCID ; Utrilla, Pilar M.
Issue Date1-Dec-2019
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function 10(12): 7793-7805 (2019)
AbstractAnti-inflammatory properties of artichoke pectin and modified fractions (arabinose- and galactose-free) used at two doses (40 and 80 mg kg−1) in mice with colitis induced by dextran sulfate sodium have been investigated. Expression of pro-inflammatory markers TNF-α and ICAM-I decreased in groups of mice treated with original and arabinose-free artichoke pectin while IL-1β and IL-6 liberation was reduced only in mice groups treated with original artichoke pectin. A decrease in iNOS and TLR-4 expression was observed for most treatments. Intestinal barrier gene expression was also determined. MUC-1 and Occludin increased in groups treated with original artichoke pectin while MUC-3 expression also increased in arabinose-free pectin treatment. Galactose elimination led to a loss of pectin bioactivity. Characteristic expression profiles were established for each treatment through artificial neural networks showing high accuracy rates (≥90%). These results highlight the potential amelioration of inflammatory bowel disease on mice model colitis through artichoke pectin administration.
Publisher version (URL)http://doi.org/10.1039/C9FO02221J
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