English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/204822
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Intestinal anti-inflammatory effects of artichoke pectin and modified pectin fractions in the dextran sulfate sodium model of mice colitis. Artificial neural network modelling of inflammatory markers

AuthorsSabater, Carlos CSIC ORCID ; Molina-Tijeras, Jose Alberto; Vezza, Teresa; Corzo, Nieves CSIC ORCID ; Montilla, Antonia CSIC ORCID ; Utrilla, Pilar M.
Issue Date1-Dec-2019
PublisherRoyal Society of Chemistry (UK)
CitationFood and Function 10(12): 7793-7805 (2019)
AbstractAnti-inflammatory properties of artichoke pectin and modified fractions (arabinose- and galactose-free) used at two doses (40 and 80 mg kg−1) in mice with colitis induced by dextran sulfate sodium have been investigated. Expression of pro-inflammatory markers TNF-α and ICAM-I decreased in groups of mice treated with original and arabinose-free artichoke pectin while IL-1β and IL-6 liberation was reduced only in mice groups treated with original artichoke pectin. A decrease in iNOS and TLR-4 expression was observed for most treatments. Intestinal barrier gene expression was also determined. MUC-1 and Occludin increased in groups treated with original artichoke pectin while MUC-3 expression also increased in arabinose-free pectin treatment. Galactose elimination led to a loss of pectin bioactivity. Characteristic expression profiles were established for each treatment through artificial neural networks showing high accuracy rates (≥90%). These results highlight the potential amelioration of inflammatory bowel disease on mice model colitis through artichoke pectin administration.
Publisher version (URL)http://doi.org/10.1039/C9FO02221J
URIhttp://hdl.handle.net/10261/204822
DOIhttp://dx.doi.org/10.1039/C9FO02221J
ISSN2042-6496
E-ISSN2042-650X
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
Intestinalinflamma.pdf3,1 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.