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Title

New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies

AuthorsQuero, Carmen CSIC ORCID ; Rosell, Gloria CSIC; Jiménez, Óscar; Rodríguez Ropero, Sergio; Bosch, María Pilar CSIC; Guerrero, Ángel CSIC ORCID
KeywordsEnzyme inhibitors
Difluoromethyl ketones (DFMKs)
Difluoroaldehydes (DFAs)
Pest control
Issue DateMar-2003
PublisherElsevier
CitationBioorganic and Medicinal Chemistry 11(6): 1047-1055 (2003)
AbstractA variety of new fluorinated chemicals have been prepared for the first time and tested as inhibitors of esterases, one of the main enzymes involved in pheromone catabolism, in two economically important pests, the Egyptian armyworm Spodoptera littoralis (SL) and the Mediterranean corn borer Sesamia nonagrioides (SN). Using the respective major component of the pheromone as substrate, the Km and Vmax of the antennal esterase of both insects resulted to be 5.66×10−4 M and 8.47×10−6 Mmin−1 for SL and 1.61×10−7 M and 1.25×10−7 Mmin−1 for SN, pointing out that SN esterase has a higher affinity for its corresponding substrate than SL. In general, the trifluoromethyl ketones (TFMKs) exhibited higher inhibitory potency than the corresponding difluoromethyl ketones (DFMKs) or difluoroaldehydes (DFAs). The compounds appeared to hydrate differently in aqueous solution, the extent of hydration following the order: α,α-DFMKs<α,α-difluoro-β-thioalkylmethyl ketones<TFMKs<β-thiotrifluoromethyl ketones<α,α-DFAs. No clear correlation has been found between the Khyd and the inhibitory potency and no specificity has been found when the chemicals were assayed on extracts of both insects.
Description9 pages, 1 figure, 3 schemes, 4 tables.-- PMID: 12614892 [PubMed].-- Available online Nov 20, 2002.
Publisher version (URL)http://dx.doi.org/10.1016/S0968-0896(02)00467-4
URIhttp://hdl.handle.net/10261/20473
DOI10.1016/S0968-0896(02)00467-4
ISSN0968-0896
E-ISSN1464-3391
Appears in Collections:(IQAC) Artículos

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