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Title

Coronavirus epidemics

AuthorsEnjuanes Sánchez, Luis
Issue Date27-Sep-2016
Citation10th Annual Meeting EPIZONE (2016)
AbstractThe identification of the genes involved in coronavirus (CoV) virulence and in signaling pathways contributing to pathogenesis has been addressed using SARS- and MERS-CoVs. SARS-CoV non-essential genes have been deleted using a reverse genetics system. Among them, deletion of E gene led to an attenuated phenotype (SARS-CoV-¿E), which is a vaccine candidate. The expression of proinflammatory cytokines was reduced in lungs of mice infected with a mouse adapted SARS-CoV-MA15-¿E compared to lungs infected with the wild type virus. In infections by SARS-CoV with and without E protein, NF-¿B was the only proinflammatory pathway differentially activated. Addition of an inhibitor of NF-¿B led to a reduced inflammatory response after SARS-CoV infection and to an increase in mice survival. Therefore, these inhibitors could serve as antivirals.
DescriptionTrabajo presentado en la 10th Annual Meeting EPIZONE: "Going viral", celebrada en Madrid (España), el 27 de septiembre de 2016
URIhttp://hdl.handle.net/10261/204695
Appears in Collections:(VICYT) Colección Especial COVID-19
(CNB) Comunicaciones congresos
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