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Title: | Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015) |
Authors: | Palomo, Valle ![]() ![]() |
Keywords: | Alzheimer’s disease Cancer GSK-3 inhibitors Stem cells Regenerative medicine |
Issue Date: | 21-Nov-2016 |
Publisher: | Taylor & Francis |
Citation: | Expert opinion on therapeutic patents 27(6) 657-666 (2016) |
Abstract: | Introduction: Glycogen synthase kinase (GSK-3) is a serine/threonine kinase that phosphorylates more than one hundred different sequences within proteins in a variety of different pathways. It is a key component of a remarkably large number of cellular processes and diseases. Imbalance of GSK-3 activity is involved in various prevalent pathological diseases, such as diabetes, neurodegenerative diseases and cancer.Understanding its role in different disorders has been central in the last several decades and there has been a significantly large development of GSK-3 inhibitors, some of which, show promising results for the treatment of these devastating diseases.Areas covered: This review covers patent literature on GSK-3 inhibitors and their applications published and/or granted between 2014 and 2015.Expert opinion: GSK-3 inhibitors have gained a prominent role in regenerative medicine based in their ability to modulate stem cells. Moreover, some allosteric modulators of GSK-3 emerge as safe compounds for chronic treatments. |
Description: | 30 p.-5 fig. |
Publisher version (URL): | https://doi.org/10.1080/13543776.2017.1259412 |
URI: | http://hdl.handle.net/10261/204684 |
ISSN: | 1354-3776 10.1080/13543776.2017.1259412 |
E-ISSN: | 1744-7674 |
Appears in Collections: | (CIB) Artículos |
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File | Description | Size | Format | |
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Expert Opinion on Therapeutic Patents_palomo_2016.pdf | Postprint | 653,63 kB | Adobe PDF | ![]() View/Open |
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