Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/204552
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invite to open peer review
Title

Anti-obesity effect of cocoa proteins (Theobroma cacao L.) variety “Criollo” and the expression of genes related to the dysfunction of white adipose tissue in high-fat diet-induced obese rats

AuthorsCoronado-Cáceres, Luis Jorge; Rabadán-Chávez, Griselda; Quevedo-Corona, Lucía; Hernández-Ledesma, Blanca CSIC ORCID ; Miliar Garcia, Angel; Mojica, Luis; Lugo-Cervantes, Eugenia
KeywordsFood protein
Obesity
Anti-inflammatory
Adipose tissue
Gene expression
Functional foods
Issue Date2019
PublisherElsevier
CitationJournal of Functional Foods 62: 103519 (2019)
AbstractThe objective of this work was to evaluate if Cocoa Proteins (CP) from the cocoa-bean were able to reduce factors related to obesity and activated related gene targets against white adipose tissue (WAT) dysfunction in a rat model of hypercaloric diet-induced obesity. The results showed that the administration with 150 mg/kg/day of CP on a hypercaloric diet reduces body-weight gain, relative weight of WAT, serum triglycerides, NEFAs, insulin, and leptin levels, and pro-inflammatory factors, with an increase in serum HDL levels, activation (AMPK, PPAR-γ, PPAR-α, SIRT1, Plin1, and PGC-1α) and repression (TNF-α, SREBP-1c, Leptin and ACC) of the mRNA of transcription factors and proteins related to WAT dysfunction. The CP prevented dysfunction in WAT who is related to obesity by down-regulation of factors related to lipogenesis and up-regulation of those related to energy expenditure, lowering the release of triglycerides and NEFAs into peripheral tissues, thus decreasing pro-inflammatory processes.
Publisher version (URL)https://doi.org/10.1016/j.jff.2019.103519
URIhttp://hdl.handle.net/10261/204552
DOI10.1016/j.jff.2019.103519
ISSN1756-4646
E-ISSN2214-9414
Appears in Collections:(CIAL) Artículos




Files in This Item:
File Description SizeFormat
accesoRestringido.pdf59,24 kBAdobe PDFThumbnail
View/Open
Show full item record

CORE Recommender

SCOPUSTM   
Citations

11
checked on May 20, 2024

WEB OF SCIENCETM
Citations

8
checked on Feb 25, 2024

Page view(s)

165
checked on May 27, 2024

Download(s)

29
checked on May 27, 2024

Google ScholarTM

Check

Altmetric

Altmetric


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.